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Technology features
- In-vivo protein inactivation based on a controlled cross-reactive antibody induction of specific immune response.
- Fast functional Knock-out :
- In 6 monthsfor the first animals
- 2 months for the subsequent ones
- Functional KO models in all mammals
- Easy switching
- from a strain to another (1 month operation)
- from a species to another (1 -6 months)
- Functional KO directly in adult animals or at different animal ages
- Selective inactivation of proteins:
- from alternative splicing
- from enzymatic cleavage
- Stable long-term phenotypes
- Inactivation Kinetics
- Possibility of phenotype reversion
Benefits:
- Inactivation on the protein level
- Working directly on the most relevant species for functional studies
- Generation of a functional KO in the desired animal model or strain for target validation.
- Functional characterization of endogenous secreted proteins and receptorsenabled
in different physiological or pathological situations.
- Possibility of kinetic study
- Quality control : Design of dedicated validation tests
- Rapid and serial analysis of a large protein target range.
- Save time and money:
- starting in the same time in-vivo and in-vitro tests
- with more predictive information thanks to the use of the most relevant model
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